- 15-11-2023Significant changes in human lifestyle have occurred in the past century, leading to a substantial increase in obesity. This has…
- 15-11-2023Glucocorticoids (GCs) bind to the glucocorticoid receptor (GR) and are effective anti-inflammatories, a.o. against rheumatoid arthritis (RA), but may also…
- 15-11-2023Aim: Glucagon-like peptide-1 receptor (GLP1R) agonists are currently used in the clinic for the treatment of type 2 diabetes mellitus…
- 15-11-2023Background:Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by brittle, fracture-prone bones. Individuals with OI may also have extraskeletal…
- 15-11-2023Obesity is a major global health issue arising from a combination of environmental factors and genetic predisposition. Research highlights the…
- 15-11-2023Amidst the continuum of internal and external changes associated with aging, there is a persistent decline in bone mass and…
- 15-11-2023Background: Adrenocortical carcinoma (ACC) is a rare but devastating malignancy (5-year survival 18-57%), with limited treatment options. Currently mitotane is…
- 15-11-2023Endocrine therapies effectively treat breast cancer (BC), but resistance to treatment is common. Currently, 214 clinical trials are registered to…
- 06-11-2023Melanocortin 2 receptor accessory protein 2 (MRAP2) is a membrane-bound protein expressed on hypothalamic neurons that modulate the function of…
- 27-10-2023Background Optimal cortisol replacement therapy for patients with adrenal insufficiency (adr-ins) should mimic the cortisol diurnal rhythm. The standard of…
