- 18-08-2023IntroductionMonitoring steroid hormone levels of patients with endocrine disorders, such as congenital adrenal hyperplasia (CAH) and disorders of sex development…
- 17-07-2023Endogenous steroid hormones exert robust effects on inflammatory and immune processes, but the immunological activities of steroidogenesis precursors remain largely…
- 30-11-2022It is well established that stress and the attendant rise in glucocorticoids (GCs) results in immune suppression. Indeed, the anti-inflammatory…
- 30-11-2022Background: The nuclear receptor Nur77 (NR4A1) has a crucial function in macrophages' resolution phase of inflammation. Nur77 can trans-repress the…
- 30-11-2022The glucocorticoid receptor (GR) is a crucial drug target in multiple myeloma as its activation with glucocorticoids triggers myeloma cell…
- 30-11-2022Nur77 (NR4A1) belongs to the NR4A family of orphan nuclear receptors. These nuclear receptors are essential in immune cell differentiation…
- 30-11-2022In the brain, mineralocorticoid (MR) and glucocorticoid receptors (GR) act as transcription factors to mediate effects of glucocorticoid (GC) hormones…
- 30-11-2022Next Generation Risk Assessment (NGRA) can use the Dietary Comparator Ratio (DCR) to evaluate the safety of a defined exposure…
- 30-11-2022CORT118335 (miricorilant) is a GR ligand that acts as a selective modulator of GR activity by inducing a combination of…
- 29-11-2022Introduction:Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy with limited treatment options so far. Possible treatments are usually studied…
