- 18-11-2023The androgen receptor (AR) signaling is the most prominent signaling pathway driving tumorigenesis in prostate cancer. As a result, androgen-deprivation…
- 15-11-2023It is well established that stress and the attendant rise in glucocorticoids (GCs) results in immune suppression. However, recent evidence…
- 15-11-2023Reduced brown adipose tissue (BAT) activity is considered to contribute to obesity development. BAT activity is decreased in both women…
- 15-11-2023IntroductionTraditional in vitro liver models have limitations in mimicking the native tissue microenvironment. 3D liver models address these shortcomings by…
- 15-11-2023BackgroundThe Farnesoid X Receptor (FXR) is a nuclear receptor activated by bile acids. Upon activation, FXR regulates transcription of genes…
- 15-11-2023The Farnesoid X Receptor (FXR) is a nuclear receptor activated by bile acids, which acts as a metabolic homeostat for…
- 15-11-2023Disrupted thyroid hormone (TH) homeostasis has devastating effects on human neurodevelopment. THs are critical signaling molecules in neurodevelopment, acting on…
- 15-11-2023Obesity is considered a global pandemic and obesity-associated diseases, such as atherosclerotic cardiovascular disease (asCVD), are on the rise. In…
- 14-11-2023Microglia are the resident brain immune cells, initiating local immune responses. It is well known that microglia, upon activation, show…
- 13-11-2023Mutations of the androgen receptor (AR) associated with prostate cancer and androgen insensitivity syndrome may profoundly influence its structure, protein…