- 01-12-2022In the EU, 15 million people annually take systemic glucocorticoids (GCs) such as dexamethasone. GCs bind to the glucocorticoid receptor…
- 30-11-2022It is well established that stress and the attendant rise in glucocorticoids (GCs) results in immune suppression. Indeed, the anti-inflammatory…
- 30-11-2022Background:Cardiovascular disease (CVD) is a precarious complication of type 1 diabetes (T1D). Alongside glycaemic control, lipid and blood pressure (BP)…
- 30-11-2022Background: The nuclear receptor Nur77 (NR4A1) has a crucial function in macrophages' resolution phase of inflammation. Nur77 can trans-repress the…
- 30-11-2022Background: Persistent organic pollutants are organic chemicals (such as pesticides like Dichloro-diphenyl-dichloroethylene [DDE] and industrial chemicals like polychlorinated biphenyls [PCBs])…
- 30-11-2022Background: Reference intervals of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) are statistically defined by the 2.5th-97.5th percentiles, which do…
- 30-11-2022The glucocorticoid receptor (GR) is a crucial drug target in multiple myeloma as its activation with glucocorticoids triggers myeloma cell…
- 30-11-2022Background: Chronic nonbacterial osteomyelitis (CNO) is a rare auto-inflammatory bone disease. CNO, especially the adult variant, lacks guidelines, resulting in…
- 30-11-2022The circadian timing system coordinates daily cycles in physiological functions, including glucose metabolism and insulin sensitivity. However, how continuous enteral…
- 30-11-2022Nur77 (NR4A1) belongs to the NR4A family of orphan nuclear receptors. These nuclear receptors are essential in immune cell differentiation…
