- 29-11-2022The androgen receptor (AR) and the glucocorticoid receptor (GR) have a very similar mechanism of action. Despite these similarities, androgens…
- 28-11-2022The Farnesoid-X-Receptor (FXR) is a transcription factor activated by bile acids, which acts as a metabolic homeostat for lipids, glucose and…
- 28-11-2022Purpose: Corticosteroids are a major risk factor for central serous chorioretinopathy (CSC), a posterior eye disease with a poorly understood…
- 17-11-2022Peroxisome proliferator-activated receptor g (PPARg), a member of the nuclear receptor superfamily of ligand inducible transcription factors, is viewed as…
- 16-11-2022Glucocorticoids are steroid drugs that are used to treat various inflammatory diseases. However, the severity of their side effects limits…
- 15-11-2022Patients with mutations in the β-subunit of the succinate dehydrogenase (SDHB) have the highest risk to develop metastatic phaeochromocytomas and…
- 15-11-2022It is well established that an obesogenic high-fat diet (HFD) causes brain inflammation, which eventually leads to obesity. Microglia are…
- 15-11-2022How steroid hormone receptors (SHRs) orchestrate transcriptional activity remains to be completely understood. Upon ligand activation, SHRs translocate to the…
- 14-11-2022In women, elevated levels of androgens, such as in PCOS, increase the risk of obesity and diabetes. Altered adipose tissue…
- 14-11-2022Background: Lenvatinib is a multitarget tyrosine kinase inhibitor (TKI) approved for the treatment of metastatic differentiated thyroid cancer (TC). The…
